iBIG: An Integrative Network Tool for Supporting Human Disease Mechanism Studies

iBIG: An Integrative Network Tool for Supporting Human Disease Mechanism Studies

Understanding the mechanism of complex human diseases is a major scientific challenge. Towards this end, we developed a web-based network tool named iBIG (stands for integrative BIoloGy), which incorporates a variety of information on gene interaction and regulation. The generated network can be annotated with various types of information and visualized directly online. In addition to the gene ...

iPINBPA: An Integrative Network-Based Functional Module Discovery Tool for Genome-Wide Association Studies

We introduce the integrative protein-interaction-network-based pathway analysis (iPINBPA) for genome-wide association studies (GWAS), a method to identify and prioritize genetic associations by merging statistical evidence of association with physical evidence of interaction at the protein level. First, the strongest associations are used to weight all nodes in the PPI network using a guilt- by...

Supporting Information on “The Human Disease Network”

zinc and its importance for human health: an integrative review

normal 0 false false false en-us x-none ar-sa since its first discovery in an iranian male in 1961, zinc(zn) deficiency in humans is now known to be an important malnutrition problem world-wide. it is more prevalent in areas of high cereal and low animal food consumption. the diet may not necessarily be low in zinc, but its bio-availability plays a major role in its absorption. phytic acid is t...

Nursing human resource management facing Covid-19: an integrative review

Introduction: human resource management is an important part of an emergency plan in the face of major events such as the outbreak of an infectious disease that has become a pandemic. Proper employment of nurses is essential to ensure the continuity of work and guarantee adequate human resource in response to increasing demand.  The purpose of this study was to identify the actions and experie...